164602
Aminopeptidase N Inhibitor
3-Nitro-2-(2-nitrophenyl)-4-oxo-4H-1-benzopyran-8-acetic acid, 2′,3-Dinitroflavone-8-acetic acid, APN/CD13 Inhibitor
For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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This product has been discontinued.
We apologize for the inconvenience, but we do not currently have an alternative product. For related products, please refer to our complete listing of protease inhibitors. Please read the alternative product documentation carefully and contact technical service if you need additional information.
A dinitroflavone compound that acts as a selective, reversible, and competitive inhibitor of aminopeptidase N (APN/CD13; IC50 = 25 µM in U937 cells). Displays ~2-3 fold lower inhibition potency than Bestatin (Cat. No. 200484), but is not cytotoxic. Does not induce apoptosis, and only weakly affects the activities of MMP-9, angiotensin converting enzyme, neural endopeptidase, γ-glutamyl transpeptidase, DPPIV, and cathepsin-G even at concentrations as high as 1 mM.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | APN/CD13 | ||
| Primary Target IC50 | 25 µM | ||
| Molar mass | 370.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Reversible | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C17H10N2O8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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