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| Section 1. Product and Company Identification |
| Product Name | Formic Acid / Acetonitrile 0.1% Mobile Phase | Product Code | FX0437P |
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| For More Information Call | In Case of Emergency Call |
| 856-423-6300 Technical Service
Monday-Friday: 8:00 AM - 5:00 PM |
800-424-9300 CHEMTREC (USA)
613-996-6666 CANUTEC (Canada) 24 Hours/Day: 7 Days/Week |
| Synonym | None. |
| Material Uses | Analytical reagent.
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| Chemical Family | Solution. |
| Section 2. Composition and Information on Ingredients |
| Component | CAS # | % by Weight |
| Acetonitrile | 75-05-8 | 99.9-99.95 |
| Formic Acid | 64-18-6 | 0.05-0.1 |
| Section 3. Hazards Identification |
| Physical State and Appearance | Liquid. |
| Emergency Overview | DANGER!
POISON! FLAMMABLE LIQUID AND VAPOR. VAPOR MAY CAUSE FLASH FIRE. HARMFUL IF INHALED, ABSORBED THROUGH SKIN OR SWALLOWED. MAY CAUSE RESPIRATORY TRACT, EYE AND SKIN IRRITATION. CONTAINS MATERIAL WHICH CAUSES DAMAGE TO THE FOLLOWING ORGANS: KIDNEYS, LIVER, CARDIOVASCULAR SYSTEM, RESPIRATORY TRACT, SKIN, CENTRAL NERVOUS SYSTEM, EYE, LENS OR CORNEA. |
| Routes of Entry | Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion. |
| Potential Acute Health Effects |
| Eyes | May be hazardous in case of eye contact (irritant). |
| Skin | Hazardous in case of skin contact (permeator). May be hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. |
| Inhalation | Hazardous in case of inhalation. May be hazardous in case of inhalation (lung irritant). |
| Ingestion | Hazardous in case of ingestion. |
| Potential Chronic Health Effects |
| Carcinogenic Effects | This material is not known to cause cancer in animals or humans. |
| Additional information See Toxicological Information (section 11) |
| Medical Conditions Aggravated by Overexposure: | Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. |
| Section 4. First Aid Measures |
| Eye Contact | Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. |
| Skin Contact | In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. |
| Inhalation | If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. |
| Ingestion | If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. |
| Section 5. Fire Fighting Measures |
| Flammability of the Product | Product will burn. |
| Auto-ignition Temperature | The lowest known value is 524.05°C (975.3°F) (ACETONITRILE). |
| Flash Points | Closed cup: 5.9°C (42.6°F). |
| Flammable Limits | The greatest known range is LOWER: 3% UPPER: 16% (ACETONITRILE) |
| Products of Combustion | These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). |
| Fire Hazards in Presence of Various Substances | Highly flammable in presence of open flames, sparks and static discharge, of shocks, of heat, of oxidizing materials. |
| Explosion Hazards in Presence of Various Substances | Risks of explosion of the product in presence of static discharge:
Highly flammable in presence of open flames, sparks and static discharge. Highly explosive in presence of open flames, sparks and static discharge. Risks of explosion of the product in presence of mechanical impact: Highly flammable in presence of shocks. Highly explosive in presence of shocks. |
| Fire Fighting Media
and Instructions |
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use alcohol foam, water spray or fog. Cool containing vessels with water jet in order to prevent pressure build-up, autoignition or explosion. |
| Protective Clothing (Fire) | Be sure to use an approved/certified respirator or equivalent. |
| Special Remarks on Fire Hazards | Dangerous fire and explosion risk. Vapor may travel considerable distance to source of ignition and flash back. (ACETONITRILE) |
| Special Remarks on Explosion Hazards | Not available. |
| Section 6. Accidental Release Measures |
| Small Spill and Leak | Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. |
| Large Spill and Leak | Keep away from heat. Keep away from sources of ignition. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. |
| Spill Kit Information | The following EMD Chemicals Inc. SpillSolv ® absorbent is recommended for this product: SX1330 Solvent Treatment Kit |
| Section 7. Handling and Storage |
| Handling | Keep away from heat, sparks and flame. Keep container closed. Avoid breathing vapors or spray mists. Do not get in eyes, on skin, or on clothing. Do not ingest. |
| Storage | Keep container in a cool, well-ventilated area. |
| Section 8. Exposure Controls/Personal Protection |
| Engineering Controls | Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective occupational exposure limits. Ensure that eyewash stations and safety showers are proximal to the work-station location. |
| Personal Protection |
| Eyes | Splash goggles. |
| Body | Lab coat. |
| Respiratory | Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. |
| Hands | Gloves. |
| Feet | Not applicable. |
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| Personal Protection in Case of a Large Spill | Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. |
| Product Name | Exposure Limits |
| Acetonitrile | EH40-OES (United Kingdom (UK), 1997).
STEL: 102 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 68 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). ACGIH (United States, 1996). STEL: 101 mg/m3 TWA: 67 mg/m3 NIOSH REL (United States, 1994). TWA: 34 mg/m3 10 hour(s). TWA: 20 ppm 10 hour(s). OSHA (United States, 1989). STEL: 105 mg/m3 TWA: 70 mg/m3 BMWA_MAK (Austria, 2001). Skin STEL: 280 mg/m3 4 times per shift, 15 minute(s). STEL: 160 ppm 4 times per shift, 15 minute(s). TWA: 70 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). NOHSC (Australia, 2002). Skin Notes: Documentation for the substances with this footnote can be found in the 5th Edition of the ACGIH documentation of the threshold limit values and biological exposure indices.1 For all other substances with 'H' in Column 7 the documentation can be found i n the 6th Edition of the ACGIH documentation of the threshold limit values and biological exposure indices.2 STEL: 101 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 67 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). Lijst Grenswaarden (Belgium, 2002). VCD: 102 mg/m3 15 minute(s). VCD: 60 ppm 15 minute(s). VL: 68 mg/m3 8 hour(s). VL: 40 ppm 8 hour(s). SUVA (Switzerland, 2001). Skin Kurzzeitsgrenzwerte: 140 mg/m3 15 minute(s). Kurzzeitsgrenzwerte: 10 mg/m3 15 minute(s). Form: Dust Kurzzeitsgrenzwerte: 80 ppm 15 minute(s). MAK: 70 mg/m3 8 hour(s). MAK: 5 mg/m3 8 hour(s). Form: Dust MAK: 40 ppm 8 hour(s). MAK-Werte Liste (Germany, 2000). Spitzenbegrenzung: 136 mg/m3 4 times per shift, 30 minute(s). Spitzenbegrenzung: 80 ML/M3 4 times per shift, 30 minute(s). TWA: 68 mg/m3 8 hour(s). TWA: 40 ML/M3 8 hour(s). TRGS900 MAK (Germany, 2002). Skin Spitzenbegrenzung: 272 mg/m3 Spitzenbegrenzung: 160 ppm TWA: 68 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). Arbejdstilsynet (Denmark, 2000). GV: 70 mg/m3 8 hour(s). GV: 40 ppm 8 hour(s). INSHT (Spain, 2001). STEL: 102 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 68 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). EU OEL (Europe, 1991). Notes: Indicative TWA: 70 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). Työterveyslaitos (Finland, 2002). Skin STEL: 100 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 68 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). INRS (France, 1999). Skin Notes: Advisory VME: 70 mg/m3 8 hour(s). VME: 40 ppm 8 hour(s). NAOSH (Ireland, 2002). STEL: 105 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). OEL: 70 mg/m3 8 hour(s). OEL: 40 ppm 8 hour(s). Ministry of Labor (KR, 1997). Skin STEL: 105 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 70 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). Secretary of Work and Social Security (MX, 1994). CCT: 105 mg/m3 15 minute(s). CCT: 60 ppm 15 minute(s). CPT: 70 mg/m3 8 hour(s). CPT: 40 ppm 8 hour(s). Nationale MAC-lijst (Netherlands, 2003). Notes: Administrative TGG 8 uur: 70 mg/m3 8 hour(s). TGG 8 uur: 40 ppm 8 hour(s). Arbeidstilsynet (Norway, 2001). AN: 50 mg/m3 8 hour(s). AN: 30 ppm 8 hour(s). NZ OSH (NZ, 1994). Skin STEL: 101 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 67 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). AFS (Sweden, 2000). KTV: 100 mg/m3 15 minute(s). KTV: 60 ppm 15 minute(s). NGV: 50 mg/m3 8 hour(s). NGV: 30 ppm 8 hour(s). ACGIH TLV (United States, 2002). Skin Notes: 2002 Adoption. Refers to Appendix A -- Carcinogens. TWA: 20 ppm 8 hour(s). OSHA PEL (United States, 1974). TWA: 70 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). OSHA PEL 1989 (United States, 1989). STEL: 105 mg/m3 15 minute(s). STEL: 60 ppm 15 minute(s). TWA: 70 mg/m3 8 hour(s). TWA: 40 ppm 8 hour(s). |
| Formic Acid | AUVA (Austria, 1995).
Spitzenbegrenzung: 18 mg/m3 8 times per shift, 5 minute(s). Spitzenbegrenzung: 10 ppm 8 times per shift, 5 minute(s). TWA: 9 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). Belgium Minister of Labour (Belgium, 1998). VCD: 19 mg/m3 15 minute(s). VCD: 10 ppm 15 minute(s). VL: 9.5 mg/m3 8 hour(s). VL: 5 ppm 8 hour(s). BAUA (Germany, 1997). Spitzenbegrenzung: 9 mg/m3 Spitzenbegrenzung: 5 ppm TWA: 9 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). DK-Arbejdstylsinet (Denmark, 1996). GV: 9 mg/m3 8 hour(s). GV: 5 ppm 8 hour(s). 80/1107/EEC (Europe, 1991). TWA: 5 mg/m3 8 hour(s). TWA: 9 ppm 8 hour(s). Tyterveyslaitos (Finland, 1998). STEL: 19 mg/m3 15 minute(s). STEL: 10 ppm 15 minute(s). TWA: 10 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). INRS (France, 1996). VLE: 9 mg/m3 15 minute(s). VLE: 5 ppm 15 minute(s). National Authority for Occupational Safety/Health (Ireland, 1999). OEL: 9 mg/m3 8 hour(s). OEL: 5 ppm 8 hour(s). Arbeidsinspectie (Netherlands, 1999). TGG 8 uur: 9 mg/m3 8 hour(s). TGG 8 uur: 5 ppm 8 hour(s). N-Arbeidstylsinet (Norway, 1996). AN: 9 mg/m3 8 hour(s). AN: 5 ppm 8 hour(s). AFS (Sweden, 1996). KTV: 9 mg/m3 15 minute(s). KTV: 5 ppm 15 minute(s). NGV: 5 mg/m3 8 hour(s). NGV: 3 ppm 8 hour(s). EH40-OES (United Kingdom (UK), 1997). TWA: 9.6 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). ACGIH (United States, 1994). STEL: 19 mg/m3 15 minute(s). STEL: 10 ppm 15 minute(s). TWA: 9.4 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). NIOSH REL (United States, 1994). TWA: 9 mg/m3 10 hour(s). TWA: 5 ppm 10 hour(s). OSHA Final Rule (United States, 1989). TWA: 9 mg/m3 8 hour(s). TWA: 5 ppm 8 hour(s). |
| Section 9. Physical and Chemical Properties |
| Odor | Not available. |
| Color | Not available. |
| Physical State and Appearance | Liquid. |
| Molecular Weight | Not applicable. |
| Molecular Formula | Not applicable. |
| pH | Not available. |
| Boiling/Condensation Point | The lowest known value is 81.72°C (179.1°F) (ACETONITRILE). |
| Melting/Freezing Point | May start to solidify at -41.85°C (-43.3°F) based on data for: ACETONITRILE. |
| Critical Temperature | The lowest known value is 274.8°C (526.6°F) (ACETONITRILE). |
| Specific Gravity | The only known value is 0.787 (Water = 1) (ACETONITRILE). |
| Vapor Pressure | The highest known value is 9.7 kPa (72.8 mmHg) (@ 20°C) (ACETONITRILE). |
| Vapor Density | The highest known value is 1.42 (Air = 1) (ACETONITRILE). |
| Volatility | 100% (v/v). (ACETONITRILE.) |
| Odor Threshold | The lowest known value is 40 ppm (ACETONITRILE) |
| Evaporation Rate | 2.33 (ACETONITRILE) compared to (n-BUTYL ACETATE=1) |
| VOC | 100 (%) |
| LogKow | Not available. |
| Solubility | Soluble in water. |
| Section 10. Stability and Reactivity |
| Stability and Reactivity | The product is stable. |
| Conditions of Instability | Not available. |
| Incompatibility with Various Substances | Highly reactive with oxidizing agents, reducing agents, acids, alkalis. |
| Rem/Incompatibility | Not available. |
| Hazardous Decomposition Products | carbon oxides (CO, CO2) , nitrogen oxides (NO, NO2...) |
| Hazardous Polymerization | Will not occur. |
| Section 11. Toxicological Information |
| RTECS Number: |
| Acetonitrile | AL7700000 |
| Formic Acid | LQ4900000 |
| Toxicity | Acute oral toxicity (LD50): 50 mg/kg [Rabbit]. (ACETONITRILE). |
| Chronic Effects on Humans | Not available. |
| Acute Effects on Humans | May be hazardous in case of eye contact (irritant). Hazardous in case of skin contact (permeator). May be hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Hazardous in case of inhalation. May be hazardous in case of inhalation (lung irritant). Hazardous in case of ingestion. |
| Synergetic Products (Toxicologically) | Not available. |
| Irritancy | Draize Test: Not available. |
| Sensitization | Not available. |
| Carcinogenic Effects | This material is not known to cause cancer in animals or humans. |
| Toxicity to Reproductive System | Not available. |
| Teratogenic Effects | Not available. |
| Mutagenic Effects | Not available. |
| Section 12. Ecological Information |
| Ecotoxicity | Not available. |
| BOD5 and COD | Not available. |
| Toxicity of the Products of Biodegradation | The products of degradation are less toxic than the product itself. |
| Section 13. Disposal Considerations |
| EPA Waste Number | U003 D001 |
| Treatment | Specified Technology - Incineration to a level below TCA (Total Constituent Analyses) levels. Contact your local permitted waste disposal site (TSD) for permissible treatment sites. Always contact a permitted waste disposal (TSD) to assure compliance with all current local, state, and Federal Regulations.. |
| + | Section 14. Transport Information |
| DOT Classification | Proper Shipping Name: FLAMMABLE LIQUID, N.O.S. (CONTAINS ACETONITRILE)
Hazard Class: 3 UN number: UN1993 Packing Group: II RQ: Not applicable. |
| TDG Classification | Not available. |
| IMO/IMDG Classification | Proper Shipping Name: FLAMMABLE LIQUID, N.O.S. (CONTAINS ACETONITRILE)
Hazard Class: 3 UN number: UN1993 Packing Group: II RQ: Not applicable. |
| ICAO/IATA Classification | Not available. |
| Section 15. Regulatory Information |
| U.S. Federal Regulations | TSCA 8(a) PAIR: ACETONITRILE
TSCA 8(b) inventory: ACETONITRILE; FORMIC ACID TSCA 8(d) H and S data reporting: ACETONITRILE: 1982 |
| SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: ACETONITRILE; FORMIC ACID SARA 311/312 MSDS distribution - chemical inventory - hazard identification: ACETONITRILE: Fire Hazard, Immediate (Acute) Health Hazard, Delayed (Chronic) Health Hazard; FORMIC ACID: Fire Hazard, Immediate (Acute) Health Hazard, Delayed (Chronic) Health Hazard |
| SARA 313 toxic chemical notification and release reporting: ACETONITRILE 99.925% |
| Clean Water Act (CWA) 307: ACETONITRILE |
| Clean Water Act (CWA) 311: FORMIC ACID |
| Clean air act (CAA) 112 accidental release prevention: No products were found. |
| Clean air act (CAA) 112 regulated flammable substances: No products were found. |
| Clean air act (CAA) 112 regulated toxic substances: No products were found. |
| WHMIS (Canada) | CLASS B-2: Flammable liquid with a flash point lower than 37.8°C (100°F).
Class D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). |
| CEPA DSL: ACETONITRILE; FORMIC ACID |
| This product has been classifed in accordance with the hazard criteria of the Controlled Product Regulations and the MSDS contains all required information. |
| International Regulations |
| EINECS | ACETONITRILE 200-835-2
FORMIC ACID 200-579-1 |
| DSCL (EEC) | R11- Highly flammable.
R36/37/38- Irritating to eyes, respiratory system and skin. |
| International Lists | Australia (NICNAS): Acetonitrile; Formic Acid
China: Acetonitrile Germany water class: Acetonitrile Japan (MITI): Acetonitrile; Formic Acid Korea (TCCL): Acetonitrile; Formic Acid Philippines (RA6969): Acetonitrile; Formic Acid |
| China: Acetonitrile |
| State Regulations | Pennsylvania RTK: ACETONITRILE: (environmental hazard, generic environmental hazard); FORMIC ACID: (environmental hazard, generic environmental hazard)
Massachusetts RTK: ACETONITRILE; FORMIC ACID New Jersey: ACETONITRILE; FORMIC ACID |
| California prop. 65: No products were found. |
| Section 16. Other Information |
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| Changed Since Last Revision | + |
| Notice to Reader |
| The statements contained herein are based upon technical data that EMD Chemicals Inc. believes to be reliable, are offered for information purposes only and as a guide to the appropriate precautionary and emergency handling of the material by a properly trained person having the necessary technical skills. Users should consider these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use, storage and disposal of these materials and the safety and health of employees and customers and the protection of the environment. EMD CHEMICALS INC. MAKES NO REPRESENTATION OR WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE, WITH RESPECT TO THE INFORMATION HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. |
