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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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A 1:1 mixture of aristolochic acids I and II. Phenanthrenecarboxylic acid derivative found in Aristolochiaceae that has been reported to inhibit phospholipase A2 (PLA2) from various snake venoms as well as human platelet and synovial fluid PLA2. Inhibits ionophore-stimulated PLA2 activity (IC50 = 40 µM) in human neutrophils. Exhibits greater inhibitory activity towards group II PLA2 than group I PLA2.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | ionophore-stimulated PLA 2 activity | ||
| Primary Target IC50 | 40 µM | ||
| Molar mass | 341.3 | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C17H11NO7 | ||
| RTECS | CF3325000 | ||
| CAS number | 313-67-7 | ||
| Merck USA index | 14, 786 | ||
| Store and ship information | |||
|---|---|---|---|
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | +15°C to +30°C | ||
| Ship |
Ambient Temperature Only
Toxic & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25-40 Toxic by inhalation, in contact with skin and if swallowed. Limited evidence of a carcinogenic effect. |
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