197216
Bcl-xL Assay Substrate, Fluorogenic
Ac-NLWAAQRYGRELRRMSDK(fluorescein)FVD-OH
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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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A fluorescein-labeled Bad BH3 peptide that serves as an useful probe for investigating the nature of Bcl-xL- peptide interaction and as a substrate for high-throughput screening of Bcl-xL inhibitors based on fluorescence polarization. Interacts strongly with Bcl-xL with a Kd of 21.48 nM. The assay tolerates up to 8% DMSO.
| Product information | |||
|---|---|---|---|
| Peptide Sequence | Ac-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Lys(FITC-I)-Phe-Val-Asp-OH | ||
| Form | Yello lyophilized solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Molar mass | 3043.4 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Excitation max. | ~485 nm | ||
| Emission max. | ~530 nm | ||
| Solubility | DMSO | ||
| Chemical formula | C137H192N38O38S2 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue Ice Only
Standard Handling |
||
