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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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A lipophilic and more acid stable derivative of 2-Chloro-2′-deoxyadenosine (CdA; Cat. No. 220467). A better substrate than CdA for deoxycytidine kinase (dCK), the key enzyme in the activation of nucleoside analogues. Inhibits the growth of human K562 cells by blocking both ribonucleotide reduction and DNA polymerization. CAFdA is toxic to non-dividing lymphocytes and monocytes at nanomolar concentrations. Also induces apoptosis in leukemia cells.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Molar mass | 303.7 | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C10H11ClFN5O3 | ||
| RTECS | UD7473000 | ||
| CAS number | 123318-82-1 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Harmful & Carcinogenic / Teratogenic |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. |
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| R Phrase |
R: 20/21/22-36/37/38-40 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. |
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