219495
Cathepsin L Inhibitor VI
Compound 7, N-(4-Biphenylacetyl)-S-methylcysteine-(D)-Arg-Phe-β-phenethylamide
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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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An end protected tripeptide that acts as a highly selective, potent, and reversible inhibitor of human recombinant cathepsin-L (Ki = 19 nM). Resists proteolysis by cathepsin-L and mimics the mode of autoinhibition of procathepsin-L. Displays ~310- and ~210-fold greater selectivity for cathepsin-L over cathepsin-K (Ki = 5.9 µM, human recomb.) and cathepsin-B (Ki = 4.1 µM, human recomb.), respectively.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized white solid | ||
| Formulation | Supplied as a trifluoroacetate salt. | ||
| Primary Target | cathepsin L | ||
| Primary Target Ki | 19 nM | ||
| Secondary target | cathepsin-K (Ki = 5.9 µM, human recomb.) and cathepsin-B (Ki = 4.1 µM, human recomb.) | ||
| Molar mass | 735.9 | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Reversible | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C41H49N7O4S | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Standard Handling |
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