For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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A cell-permeable, reversible, ATP-competitive, and potent inhibitor of the tyrosine kinase activities of the PDGF β-receptor (β-PDGFR; IC50 = 4 µM in PAC-1 cells) and FGFR1 (IC50 = 5 µM for inhibition of tyrosine phosphorylation of p90). Does not inhibit EGFR or c-Src tyrosine kinases, even at concentrations greater than 100 µM.
| Product information | |||
|---|---|---|---|
| Form | Orange-red solid | ||
| Primary Target | B-PDGFR | ||
| Primary Target IC50 | 4 µM | ||
| Secondary target | FGFR1 (IC50 = 5 µM) | ||
| Molar mass | 264.3 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC (sum of two isomers) | ||
| Solubility | DMSO | ||
| Chemical formula | C17H16N2O | ||
| CAS number | 5812-07-7 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
