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EMD4Biosciences

Novabiochem

Novagen

Calbiochem

Inhibitor Libraries and Pathway Panels


Inhibitor Libraries and Pathway Panels

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For decades, Calbiochem® has manufactured high quality inhibitors, biochemicals, antibodies, proteins, and kits that have been cited in thousands of peer-reviewed publications. To continue with our endeavor to offer products that fast track your research, we have recently introduced the InhibitorSelect™ Libraries and Signaling Pathway Panels that contain a collection of carefully selected, structurally diverse, and potent inhibitors in convenient and cost effective formats. InhibitorSelect™ products are suitable for a wide variety of applications and are provided with comprehensive documentation.

Product Overview

InhibitorSelect™ Libraries are well-characterized, pharmacologically active, and structurally diverse InSolution™ inhibitors in 96- or 384-well format and offer:

Rich and valuable data - Our unique and expert selection of structurally diverse, well-characterized, cell-permeable, and potent inhibitors helps you get the most out of your investment

Results the first time, every time - tringent stability and HPLC purity testing on every batch of plates ensures reliable results in every experiment

InhibitorSelect™ Signaling Pathway Panels are 12-16 carefully hand-picked inhibitors in one convenient package to help you elucidate specific steps in a signaling cascade and offer:

Experience you can count on - Comprehensive documentation about each inhibitor, such as molecular structure, IC50 values, literature citations, and CAS number (where available), is provided at your fingertips

Cost savings - Each panel provides a number of pathway specific inhibitors at a fraction of what it would cost to purchase each inhibitor individually

Hassle-free results - Our best selection of inhibitors, a negative control (where applicable), DMSO, and a data sheet are provided in one convenient kit

Sample Applications

The Right Tools for Many Applications – Keep Your Research on the Fast Track

Effective Screening of Inhibitors for Influence on Proliferation and Survival of Mouse Neural Stem Cells

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Rapid Screening of Receptor Tyrosine Kinase (RTK) Inhibition Using InhibitorSelect™ Inhibitor Library I and WideScreen™ RTK pTyr and Total 7-plex Assay Kits on a Luminex® xMAP®Platform.

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Validation & Quality Control

Maximize Your Results and Minimize Your Screening Cost - With Expertly Selected Inhibitors

Inhibitors in each InhibitorSelect™ Library have been expertly selected to ensure structural diversity, cell permeability, reversibility, and potency so that you get the most out of your investment. In addition, the purity of inhibitors provided in each batch of plates is confirmed by HPLC to ensure that you get results the first time and every time. Characteristics of three Akt inhibitors included in InhibitorSelect™ Libraries are shown to demonstrate the diversity and quality of inhibitors provided.

Akt Inhibitor V, Triciribine (Cat. No. 124012)

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Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018)

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Akt Inhibitor X (Cat. No. 124020)

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Ordering Information

InhibitorSelect™ Libraries

To obtain detailed documentation or Structure Data Format (SDF) files for InhibitorSelect(TM) libraries, please contact Technical Support.

Description
96-well Library I
96-well Library II 96-well Library III 384-well Library I
Contains 80 inhibitors against mainly tyrosine, AGC, and atypical families of kinases Contains 80 inhibitors against mainly CMGC and CaMK families of kinases Contains 84 inhibitors against mainly Ser/Thr kinases and is complementary to 96-well Library I Combines inhibitors from 96-well Library I and II, for a total of 160 inhibitors in one 384-well plate
Size/Format 96-well  96-well  96-well  384-well 
Cat. No.   539744  539745  539746 539743 
ADK X   X  
Akt X   X X
AMPK   X   X
ATM   X   X
ATR   X   X
Aurora X X X X
Bcr-Abl X     X
CaMK   X X X
Cdks   X X X
cFMS X     X
Chk1,2   X X X
CK1,2   X X X
c-Met X     X
DAG X     X
DNA-PK X   X X
eEF2 X   X  
EGFR X     X
ERK   X X X
FLT3 X     X
GSK-3   X X X
IGFR X     X
IKK   X X X
IP3K X   X  
IRAK X     X
JAK X     X
JNK   X   X
LcK X     X
MAPK   X X X
MEK   X X X
MLCK   X X  
MNK1   X   X
p70 S6 X     X
p90 S6 X   X  
PAK X   X  
PDGFR X     X
PDK1 X     X
PI 3-K X   X X
PIKfyve X   X X
PIM X   X  
PKA X   X  
PKC X   X X
PKG X   X  
PKR X     X
PLK X   X  
Rho X   X X
RIP   X X  
SK   X   X
Src X X   X
Syk X X   X
TGF-ΒR X     X
TP-12 X   X  
VEGFR X     X
Wee1 X   X  

InhibitorSelect Signaling Pathway Panels

InhibitorSelect™ Pathway Panels contain 12-16 hand-picked inhibitors to help you elucidate specific steps in a signaling cascade. Best of all you’ll save money, since our focused selection of inhibitors is provided to you in one convenient kit at a fraction of what it would cost to purchase each inhibitor individually.

Signaling Pathway Panel

PI 3-K/Akt/mTOR

Cat. No. 124031

Components Cat. No.
Akt Inhibitor IV 124011
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
LY 294 440202
LY 303511 440203
PDK1/Akt/Flt Dual Pathway Inhibitor 521275
PI-103 528100
PI 3-Kγ Inhibitor 528106
PI 3-Kγ Inhibitor II 528108
PI 3-Kα Inhibitor IV 528111
PI 3-Kα Inhibitor VIII 528116
Rapamycin 553210
Ro-31-8220 557520
Wortmannin 681675
DMSO KP31817

Signaling Pathway Panel

EGFR

Cat. No. 324839

Components Cat. No.
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
PD 153035 234490
EGFR Inhibitor 324674
Et-18-OCH3 341207
JNK Inhibitor II 420119
LY 294002 440202
PD 98059 513000
PD 168393 513033
PP2 529573
Rapamycin 553210
SB 203580 559389
AG 490 658401
ZM336372 692000
DMSO KP31817

Signaling Pathway Panel

MAP Kinase

Cat. No. 444189

Components Cat. No.
ERK Inhibitor II, FR180204 328007
JNK Inhibitor II 420119
JNK Inhibitor IX 420136
MEK1/2 Inhibitor 444939
MNK1 Inhibitor 454861
MK2a Inhibitor 475863
p38 MAP Kinase Inhibitor V 506156
PD 98059 513000
Raf Kinase Inhibitor IV 553014
SB 203580 559389
Tpl2 Kinase Inhibitor 616373
ZM 336732 692000
DMSO KP31817

Signaling Pathway Panel

NF-κB

Cat. No. 481487

Components Cat. No.
BAY 11-7082 196870
IKK Inhibitor VII 401486
IRAK 1/4 Inhibitor 407601
Histone Acetyltransferase Inhibitor II 382110
Trichostatin A, Streptomyces sp. 647925
MG-132 474790
NEMO Binding Domain Peptide, Cell-Permeable 480025
NF-κB SN50 481480
PD 98059 513000
PDK1/Akt-Flt Dual Pathway Inhibitor 521275
TIRAP Inhibitor Peptide 613570
Tpl2 Kinase Inhibitor 616373
(5Z)-7-Oxozeaenol, Curvularia sp. 499610
JNK Inhibitor II 420119
DMSO KP31817

Signaling Pathway Panel

JAK/STAT

Cat. No. 420138

Components Cat. No.
PD 153035 234490
Indirubin Derivative E804 402081
JAK Inhibitor I 420099
JAK2 Inhibitor II 420132
LY 294002 440202
PP2 529573
SHP1/2 PTPase Inhibitor, NSC-87877 565851
STAT3 Inhibitor Peptide, Cell Permeable 573096
STAT3 Inhibitor III, WP1066 573097
STAT3 Inhibitor V, Statt 573099
STAT5 Inhibitor 573108
AG 490 658401
U0126 662005
DMSO KP31817

Product Citations
Angus J M Cameron, Cristina Escribano, Adrian T Saurin, Brenda Kostelecky & Peter J Parker. PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity. Nature Structural & Molecular Biology 16, 624 - 630 (2009).

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