For general questions please contact our Customer Service:
EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
09 February 2012
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Recombinant, mouse bone morphogenetic protein-6 expressed in NSO cells. An osteogenic protein belonging to the transforming growth factor-β (TGF-β) superfamily. BMP-6 has been shown to strongly induce phosphorylation and nuclear accumulation of Smad5. BMPs have also been shown to be involved in embryogenesis and morphogenesis of cells of osteoblastic lineage. A positive regulator of keratinocyte differentiation. MW: 18000 + 23000 (reducing conditions).
M.W. 18,000 and 23,000 under reducing conditions.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized | ||
| Formulation | Lyophilized from a 0.2 µm filtered solution of 35% ACN, 0.1% TFA, 50 µg BSA/µg BMP-6. | ||
| Biological activity | ED50 = 50-150 ng/ml based on the ability to induce alkaline phosphatase expression in MC3T3-E1 cells | ||
| Purity | ≥95% by SDS-PAGE | ||
| Contaminants | endotoxin: ≤100 pg/µg cytokine | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25-36/37/38 Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. |
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