Diamines attached to trityl resin
Diamine supports are specially prepared to ensure the minimum of trityl diamine cross-linking. The bulky trityl linker offers complete protection to the resin linked secondary amino functionality, thereby leaving the pendant primary amino group free to participate as a nucleophile in further reactions. Cleavage can normally be effected using 1 - 5% TFA in DCM containing 5% TIS, or with 30% HFIP in DCM.
