373400
Hh/Gli Antagonist, GANT58
4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
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EMD Chemicals, Inc.
480 S. Democrat Road
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United States
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09 February 2012
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A cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Molar mass | 392.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥95% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C24H16N4S | ||
| CAS number | 64048-12-0 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Regulatory Review |
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