420210
Jervine
11-Ketocyclopamine, (3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, Shh Signaling Antagonist III
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EMD Chemicals, Inc.
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07 February 2012
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A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 = ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 ~ 500-700 nM in s12 cells) | ||
| Molar mass | 425.6 | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC; single spot by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C27H39NO3 | ||
| RTECS | WG9700000 | ||
| CAS number | 469-59-0 | ||
| Store and ship information | |||
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Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Toxic |
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