218713
Casein Kinase II Inhibitor IV
3-(3-(2-(3,4,5-Trimethoxy-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)propionitrile, Casein Kinase II Inhibitor IV, Keratinocyte Differentiation Inducer
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EMD Chemicals, Inc.
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09 February 2012
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A cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). In addition to CKII, it is also shown to interact, directly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
| Product information | |||
|---|---|---|---|
| Form | Beige solid | ||
| Molar mass | 429.5 | ||
| Protect from Light | Yes | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥90% by HPLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C24H23N5O3 | ||
| CAS number | 863598-09-8 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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