234490
PD 153035
AG 1517, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, SU 5271, Compound 32
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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
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E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 25 pM; Ki = 6 pM). Rapidly suppresses autophosphorylation of EGFR at low nanomolar concentrations in fibroblasts or in human epidermoid carcinoma cells. Also selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression, and oncogenic transformation. A 10 mM (500 µg/139 µl) solution of PD 153035 (Cat. No. 234491) in DMSO is also available.
| Product information | |||
|---|---|---|---|
| Form | White solid | ||
| Primary Target | EGFR | ||
| Primary Target IC50 | 25 pM | ||
| Primary Target Ki | 6 pM | ||
| Molar mass | 360.2 | ||
| Protect from Light | Yes | ||
| Purity | ≥97% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C16H14BrN3O2 | ||
| CAS number | 153436-54-5 | ||
| Declaration | Sold under license of U.S. Patent 5,457,105 and European Patent 0,566,266. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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