A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 < 1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available.
| Product information | |||
|---|---|---|---|
| Form | Yellow solid | ||
| Primary Target | Akt | ||
| Primary Target IC50 | 625 nM | ||
| Secondary target | Cell proliferation (IC50 = 1.25 mM) | ||
| Molar mass | 614.6 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO | ||
| Chemical formula | C31H27IN4S | ||
| CAS number | 681281-88-9 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | +2°C to +8°C | ||
| Ship |
Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling |
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