Recombinant, mouse bone morphogenetic protein-6 expressed in NSO cells. An osteogenic protein belonging to the transforming growth factor-β (TGF-β) superfamily. BMP-6 has been shown to strongly induce phosphorylation and nuclear accumulation of Smad5. BMPs have also been shown to be involved in embryogenesis and morphogenesis of cells of osteoblastic lineage. A positive regulator of keratinocyte differentiation. MW: 18000 + 23000 (reducing conditions).
M.W. 18,000 and 23,000 under reducing conditions.
| Product information | |||
|---|---|---|---|
| Form | Lyophilized | ||
| Formulation | Lyophilized from a 0.2 µm filtered solution of 35% ACN, 0.1% TFA, 50 µg BSA/µg BMP-6. | ||
| Biological activity | ED50 = 50-150 ng/ml based on the ability to induce alkaline phosphatase expression in MC3T3-E1 cells | ||
| Purity | ≥95% by SDS-PAGE | ||
| Contaminants | endotoxin: ≤100 pg/µg cytokine | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | ≤ -70°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26-36/37/39-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
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| R Phrase |
R: 23/24/25-36/37/38 |
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