A potent, cell-permeable analog of Cyclopamine (Cat. No.
239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC
50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2
Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity.
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Product information
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Form
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Pale yellow solid
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Primary Target
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Hh signaling in Shh-light2 assay
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Primary Target IC50
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20 nM
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Secondary target
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in P2Ptch-/-cells (IC50 = 50 nM)
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Molar mass
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698.0
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Protect from Light
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Yes
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Packaged under inert gas
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Yes
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Cell permeable
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Yes
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Purity
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≥70% by HPLC (sum of two isomers)
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Solubility
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DMSO, EtOH, or MeOH
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Chemical formula
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C44H63N3O4
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Store and ship information
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Storage
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-20°C
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Ship
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Shipped with Blue Ice or with Dry Ice
Carcinogenic / Teratogenic
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