420210
Jervine
(3β, 23β)-17,23-Epoxy-3-hydroxyveratraman-11-one, 11-Ketocyclopamine, Shh Signaling Antagonist III
A cell-permeable steroidal alkaloid similar to cyclopamine (Cat. No. 239803) that displays teratogenic effects and induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 ~ 500-700 nM in s12 cells). Tomatidine (Cat. No. 614350) serves as a suitable negative control.
| Product information | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Primary Target | induces cyclopia by blocking shh (Sonic Hedgehog) signaling (IC50 ~ 500-700 nM in s12 cells) | ||
| Molar mass | 425.6 | ||
| Packaged under inert gas | Yes | ||
| Purity | ≥98% by HPLC; single spot by TLC | ||
| Solubility | DMSO or EtOH | ||
| Chemical formula | C27H39NO3 | ||
| RTECS | WG9700000 | ||
| CAS number | 469-59-0 | ||
| Store and ship information | |||
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<b>Hazardous Materials Attention:</b> Due to the nature of the Hazardous Materials in this shipment, additional shipping charges <i>may</i> be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Storage | -20°C | ||
| Ship |
Shipped with Blue Ice or with Dry Ice
Toxic |
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