475800
InSolution™ ML 3163
4-[5-(4-Fluorophenyl)-2-(4-methanesulfinyl-benzylsulfanyl)-3H-imidazol-4-yl]pyridine
A cell-permeable and reversible 2-benzylsulfanyl imidazole that combines the structural features of cytokine release inhibitors SKF-86002 (Cat. No. 567305) and p38 MAP kinase inhibitor SB 203580 (Cat. No. 559389). Acts as an effective inhibitor of TNF-α and IL-1β release from mononuclear cells in human whole blood and peripheral blood mononuclear cells (IC50 = 20.3 µM and 3.65 µM for TNF-α; 2.78 µM and 0.88 µM for IL-1β, respectively). Occupies the ATP binding site of p38 MAP kinase and inhibits its activity (IC50 = 4.0 µM).
| Product information | |||
|---|---|---|---|
| Form | Liquid | ||
| Formulation | A 10 mM (1 mg/236 µl) solution in DMSO. | ||
| Primary Target | TNF-α | ||
| Primary Target IC50 | 20.3 µM, 3.65 µM | ||
| Secondary target | 2.78 µM and 0.88 µM for IL-1b, f p38 MAP kinase activity (IC50 = 4.0 µM) | ||
| Molar mass | 423.5 | ||
| Protect from Light | Yes | ||
| Hygrocopic | Yes | ||
| Packaged under inert gas | Yes | ||
| Cell permeable | Yes | ||
| Purity | >95% by HPLC | ||
| Chemical formula | C22H18FN3OS2 | ||
| Declaration | Sold under license of U.S. Patent 6,432,988. | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Blue or Dry Ice
Irritant |
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| Safety information | |||
|---|---|---|---|
| S Phrase |
S: 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
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| R Phrase |
R: 36/38 |
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