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EMD Chemicals, Inc.
480 S. Democrat Road
08027 Gibbstown
United States
Phone: 800 854 3417
Fax: 800 776 0999
E-mail: Customer.CareDesk@emdchemicals.com
08 February 2012
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Anti-fungal and immunosuppressant. Selectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 50 pM). Prevents the translational activation of IGF-II. Shown to inhibit later signaling events such as p110Rb phosphorylation, p34cdk1 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Reported to induce apoptosis in a murine B cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
| Product information | |||
|---|---|---|---|
| Form | Clear film | ||
| Molar mass | 914.2 | ||
| Purity | ≥98% by HPLC | ||
| Solubility | DMSO or MeOH | ||
| Chemical formula | C51H79NO13 | ||
| RTECS | VE6250000 | ||
| CAS number | 53123-88-9 | ||
| Merck USA index | 14, 8114 | ||
| Store and ship information | |||
|---|---|---|---|
| Storage | -20°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
