DOTAP Chloride Cationic Lipid for Transfection
Gene and cancer therapies require innovative drug delivery solutions and transfection is a primary technology
suiting this purpose. However, most transfection agents are toxic and can be used in vitro only.
DOTAP Chloride is probably the best known cationic lipid used for transfection. It shows low toxicity and is
able to form liposomes in aqueous media, alone or in combination with other lipids. Such liposomes have a high
affinity to various cell types, e.g. angiogenic endothelial cells. They can carry their load, polar or no-polar
substance, small or large molecules, APIs or diagnostics, directly into the target cells.
Current commercially available DOTAP Chloride is amorphous in structure and exhibit limited stability, even if
stored at low temperatures. EMD Chemicals’ DOTAP Chloride is overcomes these limitations. Its DOTAP Chloride are: |
 |
• ultrapure and crystalline with enhanced stability (patent pending)
• manufactured under cGMP
• suitable for parenteral applications
Function MPEGs for API Pegylation
Pegylation of APIs is used to improve the short circulating half-life and low solubility characteristics that are
typically associated with certain drugs, therapeutic proteins and peptides. Moreover, pegylation can also improve
the pharmacological profiles of drugs. We provide MPEG-maleimide 5000, a thiol sensitive reagent and MPEG-amine
5000, a key intermediate and carboxyl-sensitive reagent, and we custom synthesize MPEG-derivatives.
For additional information, visit Merck Eprova Drug Delivery or
download our literature:
* Parenteral APIs and Excipients |
|
